Current Issues in Migraine Genetics

Current Issues in Migraine Genetics

Migraine often runs in families and is associated with both genetic and environmental factors. Clinical and genetic heterogeneity as well as the influence of environmental factors have hampered the identification of the gene responsible for migraine disorder. Family/twin studies suggest the presence of hereditary susceptibility. Several different types of mutations or association studies with g...

Migraine genetics: Part II.

Migraine clusters in families and is considered to be a strongly heritable disorder. Hemiplegic migraine is a rare subtype of migraine with aura that may occur as a familial or a sporadic condition. Three genes have been identified studying families with familial hemiplegic migraine (FHM). The first FHM gene that was identified is CACNA1A. A second gene, FHM2, has been mapped to chromosome 1 q ...

The genetics of migraine.

The search for genes involved in the pathophysiology of migraine poses major difficulties. First, there is no objective diagnostic method to assess the status of the individuals studied. Second, migraine is a polygenic multifactorial disorder. Familial hemiplegic migraine (FHM) is the only known autosomal dominant subtype of migraine. In half the families with FHM who have been studied, there a...

Breeding and Genetics SOME CURRENT ISSUES IN POPULATION GENETICS IN RELATION T O SUGARCANE BREEDING A

Four topics in modern population biology, namely, genetic architecture, stability, diversity and allozyme flexibility, are discussed in relation to sugarcane breeding. It is argued that research on the following points is likely to improve sugarcane breeding: 1) Repeated cycles of intercrossing and selection of different modes can be specifically designed to elucidate the genetic architecture o...

Genetics of migraine: New findings